Regulation of rubidium 86 outflow from pancreatic islets 4. effect of cyclic amp di butyryl cyclic amp and theophylline

Carpinelli, A.R.; Malaisse, W.J.

Acta Diabetologica Latina 17(3-4): 199-206


ISSN/ISBN: 0001-5563
Accession: 006290547

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Theophylline (1.4 mM), cAMP (1.0 mM) and dibutyryl-cAMP (0.5 mM) decreased 86Rb fractional outflow rate from rat pancreatic islets perifused in the absence of glucose. In the presence of glucose (16.7 mM) the same drugs provoked a modest increase in 86Rb fractional outflow rate. The increase in 86Rb outflow evoked by theophylline in the presence of glucose was suppressed by quinine, suggesting that it may result from an increase in cytosolic Ca2+ concentration. Changes in the cAMP content of islet cells may participate in the regulation of K+ conductance by insulin secretagogues.