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Regulatory function of thy 1 negative cells 2. spontaneous release of enhancing product by b cells cultured in vitro






Cellular Immunology 72(2): 316-325

Regulatory function of thy 1 negative cells 2. spontaneous release of enhancing product by b cells cultured in vitro

The supernatant from nonantigen- and nonmitogen-stimulated mouse spleen cells, cultured for 2 days, is effective in augmenting the IgM primary antibody response to T cell dependent (TD) antigens. The IgM and IgG secondary response to TD antigens, as well as the IgM response to T cell independent (TI) antigens is not affected. Neither T cells nor accessory cells seem to be responsible for the release of the enhancing product. The soluble factor is not a polyclonal activator of B cells, does not substitute for thymus-derived cell functions in the in vitro response to heterologous erythrocytes and does not promote the response to optimal and suboptimal doses of concanavalin A. It modulates the antibody production only in conjunction with T cells and in the presence of macrophages. Studies carried out with mouse myeloma cell lines confirmed present results obtained with normal spleen cells. A soluble product which exhibits the biological activities ascribed to the B cell enhancing factor and which prevents the activation of T suppressor cells was produced by a B cell clone that does not express Ig H or L chains.

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Accession: 006292094

PMID: 6129925



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