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Regulatory mechanisms in cell mediated immune response 5. distinct lyt subsets mediate antigen specific and antigen nonspecific suppression



Regulatory mechanisms in cell mediated immune response 5. distinct lyt subsets mediate antigen specific and antigen nonspecific suppression



Transplantation (Baltimore) 36(3): 298-303



Studies were undertaken to assess mouse T cell subpopulations mediating antigen-specific and antigen-nonspecific suppression of cytotoxic T lymphocyte (CTL) responses to alloantigens. It was 1st demonstrated that generation of the CTL response itself requires Lyt-1+2+ T cells. Subsequent studies then characterized 2 distinct suppressor pathways that regulate the CTL response. Antigen nonspecific suppression was mediated by Lyt-1+2-Ts [suppressor T] cells that were generated during in vitro culture from an Lyt-1+2- precursor population. In a 2nd pathway, antigen-specific suppression was mediated predominantly by Lyt-1-2+ Ts cells that were activated during the in vitro allosensitization of Lyt-1+2+ precursors. The in vitro CTL response to alloantigens is modulated by 2 different pathways of T-cell-mediated suppression, and these pathways are mediated by distinct Lyt-defined T cell subpopulations.

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Accession: 006292167

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PMID: 6193617



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