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Regulatory peptides in barretts esophagus


Journal of Pathology 146(3): 227-234
Regulatory peptides in barretts esophagus
Barrett's epithelium refers to the presence of ectopic mucosal types in the squamous-lined esophagus. Argentaffin and argyrophil-positive cells as well as gastrin-like immunoreactivity were documented in esophageal tissue extracts from patients with Barrett's mucosa. Esophageal (125) biopsies obtained under direct vision at endoscopy from 22 patients wtih Barrett's esophagus were systematically studied using fluorescence and peroxidase antiperoxidase single and double-staining immunocytochemical methods employing highly specific antibodies to localize the following peptide-containing cell types in Barrett's mucosa: gastrin somatostatin, gastric inhibitory polypeptide, motilin, neurotensin and pancreatic glucagon. EC [enterochromaffin] cells were localized using a cytochemical Ag staining method. EC cells and gastrin- and somatostatin-containing endocrine cells are detectable in Barrett's epithelium.

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Accession: 006292248



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