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Regulatory role of humoral factors released by macrophages in reactivity of rat lymphocytes in vitro 3. humoral factors released by lymph node macrophages regulating lymphocyte response to phyto hem agglutinin



Regulatory role of humoral factors released by macrophages in reactivity of rat lymphocytes in vitro 3. humoral factors released by lymph node macrophages regulating lymphocyte response to phyto hem agglutinin



Archivum Immunologiae et Therapiae Experimentalis 28(1): 33-44



Lymph node macrophages, derived from normal rats, generated in vitro factors enhancing or suppressing syngeneic lymph node lymphocyte stimulation in response to PHA [phytohemagglutinin] and reconstituting the PHA-dependent response of lymphocytes deprived of native macrophages. The occurrence of one of the opposite activities depended on the degree of lymphocyte stimulation by PHA. The expression of suppressing or stimulating effect on lymphocyte response to PHA of the same supernatants changed twice with their dilution, (suppression .fwdarw. enhancement .fwdarw. suppression) suggesting the existence of 2 distinct factors, suppressing and enhancing.

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