EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulatory role of testosterone on the natural defense mechanism against infection with strongyloides ratti in c 57bl 6 mice






Japanese Journal of Parasitology 33(1): 49-54

Regulatory role of testosterone on the natural defense mechanism against infection with strongyloides ratti in c 57bl 6 mice

The susceptibility to infection with S. ratti was examined at various times after castration of C57BL/6 male mice, known to be more susceptible to infection than females. The susceptibility measured by intestinal worm burden became .apprx. 1/3 of control 1 wk after castration. Three or 5 wk after castration, the susceptibility further decreased by .apprx. 1/7 of normal level. The castration was reversible, since reduced susceptibility could be restored by the treatment with physiological doses of testosterone. Female C57BL/6 mice, which are naturally resistant against infection, became susceptible after treatment with the pharmacological dose of testosterone (.apprx. 10 fold increase at 1 wk and 30 fold increase at 3 wk after the treatment). The modulating effect of testosterone was expressed at the early tissue migratory phase of infection, suggesting that testosterone-sensitive cells and/or tissues involved in the host's defense system are natural rather than specific antigen-induced.

(PDF 0-2 workdays service: $29.90)

Accession: 006292385



Related references

The crucial role of granulocytes in the early host defense against Strongyloides ratti infection in mice. Parasitology Research 86(3): 188-193, 2000

Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. Journal of Immunology 186(7): 4295-4305, 2011

Strongyloides ratti: additive effect of testosterone implantation and carbon injection on the susceptibility of female mice. Parasitology Research 85(7): 522-526, 1999

Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolution. Aging Cell 5(4): 315-323, 2006

Successful infection of mice with Strongyloides ratti. Jour Parasitol 23(1): 98, 1937

Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection. Parasite Immunology 34(7): 388-393, 2012

The occurrence of Strongyloides ratti in the tissues of mice after percutaneous infection. Journal of Helminthology 56(1): 45-50, 1982

Occurrence of strongyloides ratti in the tissues of mice after per cutaneous infection. Journal of Helminthology 56(1): 45-50, 1982

Studies on active acquired resistance, natural and artificial, in the rat to infection with Strongyloides ratti. Amer Jour Hyg 25(1): 53-65, 1937

Transfer by serum and cells of resistance to infection with Strongyloides ratti in mice. Immunology 43(2): 317-322, 1981