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Reinnervation of primate ciliary muscle following ciliary ganglionectomy

Reinnervation of primate ciliary muscle following ciliary ganglionectomy

Investigative Ophthalmology & Visual Science 28(6): 927-933

Ciliary ganglionectomy and/or postganglionic ciliary neurectomy in the cynomolgus monkey was followed by supersensitivity to intramuscular (i.m.) pilocarpine and lack of response to topical eserine and to electrical stimulation of the Edinger-Westphal nucleus. Normal responsiveness to pilocarpine and eserine returned in most instances after about 6 months. An accommodative response to stimulus of the Edinger-Westphal nucleus was also present and, as in control eyes, could be blocked by hexamethonium. Collectively, these findings demonstrate that (1) parasympathetic innervation to the ciliary muscle mediating accommodation traverses a typical peripheral autonomic synapse, almost certainly located predominantly in the ciliary ganglion; (2) by 6 months after denervation, the ciliary muscles have reinnervated; and (3) the parasympathetic pathway to the eye exhibits plasticity and capacity for regeneration.

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Accession: 006292837

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PMID: 3583631

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