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Relationship between hemo globin and serum testosterone in normal children and adolescents and in boys with delayed puberty

Relationship between hemo globin and serum testosterone in normal children and adolescents and in boys with delayed puberty

Acta Paediatrica Scandinavica 67(5): 655-658

The concentrations of Hb and serum testosterone were measured in 215 normal children and adolescents aged 7-20 yr, and in 8 boys with constitutional delayed puberty. From 14 yr on Hb and testosterone rose in normal boys and differed significantly from the stable levels observed in prepubertal children and pubertal girls. In the entire series of normal boys (n = 118, age 7-20 yr) concentrations of Hb and testosterone were closely correlated (r [correlation coefficient] = 0.73, P < 0.001). Further evidence for a major role of testosterone in the control of erythropoiesis was provided. This correlation suggests the use of serum testosterone determination for the proper selection of Hb reference ranges in boys. The respective reference ranges of Hb corresponding to testosterone levels at 0 and 30 nM were 120.5-148.5 and 143.5-171.5 g/l (95% confidence limits). Boys with delayed puberty had significantly reduced median values of Hb and testosterone for their chronological age, and 6 of the 8 boys investigated were truly anemic on this background. Their Hb concentration did appear appropriate as judged from their testosterone levels. This observation supports the idea that the selection of the relevant reference range for Hb in boys should depend on the state of physical development as expressed by serum testosterone.

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Accession: 006297090

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PMID: 696311

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