EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Relationship between hepatic malate dehydrogenase ec 1.1.1.40 and thyroid hormones in the chicken during embryogenesis and the neo natal period


, : Relationship between hepatic malate dehydrogenase ec 1.1.1.40 and thyroid hormones in the chicken during embryogenesis and the neo natal period. Endocrinology 108(1): 254-258

The synthesis of hepatic cytosol malate dehydrogenase (MDH) can be stimulated by thyroid hormones under various conditions, and consequently, this enzyme has been considered as a marker of the expression of thyroid hormone action. Since the concentrations of serum thyroid hormones increase considerably during the late phase of chick embryogenesis, the relationship between this phenomenon and liver MDH activity was studied. A delay of 5 days was observed between the increase in circulating T4 [thyroxine] and T3 [triiodothyronine] concentrations and the enhancement of MDH activity. Treatment with pharmacological doses of T4 (60 .mu.g/day) resulted in increased MDH activity 48 h after hormone administration, while hypothyroidism induced by methimazole decreased the level of the enzyme. Sex-linked differences in MDH activity were found in newborn chickens betWeen 5-9 days of age. No such differences were observed for serum T3 and T4. These findings suggest that under physiological conditions MDH activity is not directly modulated by thyroid hormones in the chick embryo. These hormones may well play a permissive role with this enzyme.


Accession: 006297102

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Milette, F.; Lehoux, J.G.; Bellabarba, D., 1981: Relationship between hepatic malate dehydrogenase and thyroid hormones in the chicken during embryogenesis and the neonatal period. The synthesis of hepatic cytosol malate dehydrogenase (MDH) can be stimulated by thyroid hormones under various conditions, and consequently, this enzyme has been considered as a marker of the expression of thyroid hormone action. Since the concen...

Tarentino, A.L.; Richert, D.A.; Westerfeld, W.W., 1966: The concurrent induction of hepatic -glycerophosphate dehydrogenase and malate dehydrogenase by thyroid hormone. The 8-10 fold increase in hepatic L-[alpha]-glycerophosphate dehydrogenase (L-glycerol-3-phosphate: cytochrome c oxidoreductase, EC 1.1.2.1) and soluble malate dehydrogenase (L-malate: TPNH oxidoreductase, EC 1.1.1.40) which occurs as a result of...

Tarentino, A.L.; Richert, D.A.; Westerfeld, W.W., 1966: The concurrent induction of hepatic alpha-glycerophosphate dehydrogenase and malate dehydrogenase by thyroid hormone. Biochimica et Biophysica Acta 124(2): 205-309

Consiglio E., 1968: Effect of thyroid hormones on the activity and structure of mitochondrial malate dehydrogenase. Biochimica Applicata 15(SUPPL 6): 403-417

Joo, C.N.; Han, J.H., 1976: Biochemical studies on ginseng saponins part 5 the effect of ginseng saponins on chicken hepatic mitochondrial succinate dehydrogenase malate dehydrogenase and alpha keto glutarate dehydrogenase. The effects of gingseng saponins, 1 of the major components of Panax ginseng roots, on several TCA [tricarboxylic acid] cycle enzymes such as succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and .alpha.-ketoglutarate dehydrogenase (.alpha...

Varrone, S.; Consiglio, E.; Covelli, I., 1970: Effects of thyroid hormones on the multiple molecular forms of mitochondrial malate-dehydrogenase. Hormones 1(3): 148-163

Milette F.; Lehoux J G.; Bellabarba D., 1978: Thyroid hormones alpha glycero phosphate dehydrogenase and malic enzyme during chick embryogenesis. Clinical Research 26(6): 845A

Wakelam, M.J.O.; Aragon, C.; Giminez, C.; Allen, M.B.; Walker, D.G., 1979: Thyroid hormones and the precocious induction of hepatic gluco kinase ec 2.7.1.2 in the neo natal rat. Oral intubation of glucose is more effective than i.p. injection in inducing the premature appearance of hepatic glucokinase in suckling rats. The inducing effect of glucose is enhanced by treatment of the animals 12 h or more earlier with 1 .mu.g...

Dordal, A.; Mazo, A.; Gelpí, J.L.; Cortés, A., 1990: Factors affecting L-malate activation of mitochondrial malate dehydrogenase from chicken liver. Mitochondrial malate dehydrogenase is activated by high concentrations of L-malate. In this paper, several factors affecting this activation on chicken liver enzyme have been investigated. The results obtained show clearly that this phenomenon is...

Chikhachev A.S.; Tsvetnenko Y.B., 1983: The expression of lactate dehydrogenase and malate dehydrogenase and cytoplasmic proteins in embryogenesis of sturgeon hybrids. The time of gene expression in embryogenesis of sturgeons (giant sturgeon [Huso huso], sterlet [Acipenser ruthenus], Russian [A. guldenstadti] and stellate sturgeons [A. stellatus]) was determined on fractionation of LDH [lactate dehydrogenase], M...