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Relationship between hormone receptors in human breast cancer and nuclear grade

Nihon Gan Chiryo Gakkai Shi 19(9): 2172-2178

Relationship between hormone receptors in human breast cancer and nuclear grade

Nuclear atypia was clasified, with original criteria, into 5 nuclear grades (NG 0-IV); NG 0 stands for the minimum atypia and NG IV for the maximum. By using this grading method, the correlation between nuclear atypia and levels of estrogen receptor (ER) and progesterone receptor (PgR) in the tumor was evaluated. The incidences of ER(+) were 100% in NG 0, 97.7% in NG I, 62.9% in NG II, 26.7% in NG III and 0 in NG IV, indicating that ER(+) rate significantly decreases as NG becomes higher. The incidences of PgR(+) were 73.3% in NG 0, 45.5% in NG I, 31.4% in NG II and 6.7% in NG III; NG IV showed an interestingly high incidence of 80.0%. NG of human breast cancer apparently can be a parameter for levels of hormone receptor, especially for ER.

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Accession: 006297149

PMID: 6530584

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