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Relationship between hydro chloric acid secretion and level of nonprotein sulfhydryl compounds in the mucosa of the gastric fundus gland of rabbits






Nihon University Journal of Medicine 23(4): 247-256

Relationship between hydro chloric acid secretion and level of nonprotein sulfhydryl compounds in the mucosa of the gastric fundus gland of rabbits

The method for quantitative analysis of glutathione was recently improved. A large quantity of low MW SH compounds (RSH) was found in the mucous membrane of the stomach fundus of mammals employing a combination of the above method and the conventional method for determining the total SH compounds. Stimulation tests were carried out for HC secretion in the stomach using histamine, gastrin and urogastrone in order to elucidate the relationship between gastric low MW SH compounds and stomach functions, i.e., the secretion and formation of HC. The results obtained from a study on rabbits revealed a marked decrease in the level of low MW SH compounds with the sole exception of glutathione. Such a decrease was not seen in the case of urogastrone, which is an inhibitor of HC secretion. A direct relationship between the HC acid secretion-formation mechanism and RSH is suggested.

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Accession: 006297174



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