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Relationship between laboratory mice and the subspecies mus musculus domesticus based on restriction endo nuclease cleavage patterns of mitochondrial dna


, : Relationship between laboratory mice and the subspecies mus musculus domesticus based on restriction endo nuclease cleavage patterns of mitochondrial dna. Japanese Journal of Genetics 55(4): 289-296

The mitochondrial DNA of the house mouse, M. musculus, in 25 different laboratory strains showed identical cleavage patterns on digestion with 9 different restriction endonucleases. The cleavage patterns were identical to those of Canadian wild mice, M. m. domesticus, but clearly different from the patterns of 3 Asian subspecies, M. m. bactrianus, M. m. castaneus and M. m. molossinus. Based on comparison of the cleavage maps of the 4 sspp., the time of divergence between M. m. domesticus and the 3 Asian subspecies was 10-2.5 .times. 106 yr. Apparently, the genetic background of laboratory mice is mainly derived from M. m. domesticus.

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