EurekaMag.com logo
+ Site Statistics
References:
48,252,460
Abstracts:
22,798,453
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Relationship between lenticular vitamin e level and cataract formation in experimentally diabetic rats


, : Relationship between lenticular vitamin e level and cataract formation in experimentally diabetic rats. Nippon Ganka Gakkai Zasshi 90(2): 313-320

To examine the relationship between lenticular vitamin E (Vit. E) level and diabetic cataract formation, we determined Vit. E and its analogues in rat lens by high-performance liquid chromatography and investigated the changes in Vit. E and lipid peroxide levels in diabetic rat lens and serum following cataract formation. We used lenses from male Wistar rats ages six weeks for the determination of Vit. E and its analogues. Male Wistar rats aged five weeks were made diabetic by a single i.p. 50 mg/kg of streptozotocin (STZ). Diabetic and control animals were killed at four days, and one, two and four weeks after injection. Although Vit. E was present in rat lens, its analogues except for .alpha.-tocopherol were not detected in the lens. The formation and development of cataract in the STZ-treated rats were observed with a photoslit lamp. No cataract could be detected one week after injection, but some vacuoles were observed in the cortical equator at two weeks and also some large, confluent vacuoles at four weeks. Lens weight and its protein content in the STZ-treated rats had decreased at four weeks after injection, while lenticular glucose content markedly increased each week after STZ injection. Vit. E level in the lens of the STZ-treated rats significantly decreased from one week after injection, and the reduction continued over the experimental period. In contrast, serum Vit. E level increased at two and four weeks after STZ injection. Lenticular lipid peroxide level in the STZ-treated rats had significantly increased at four days after injection, but thereafter remained the same in diabetic and control animals. In contrast, serum lipid peroxidase level increased continually after STZ treatment. In conclusion, we proved that Vit. E is present in rat lens and that the Vit. E is mainly .alpha.-tocopherol. In diabetic cataract formation, the reduction of Vit. E, especially .alpha.-tocopherol immediately after the increase of lipid peroxide in lens in which cataract is not yet detectable seems to be one of the causative factors.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006297432

PMID: 3706077

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Moorer W.R.; Ten Cate J.M., 1988: Demineralization by simulated plaque fluids. Caries Research 22(2): 102-103

Csordás, B.; Nagy, A.; Harmat, V.; Zsoldos-Mády, Vág.; Leveles, I.; Pintér, Ián.; Farkas, V.; Perczel, Aás., 2016: Origin of problems related to Staudinger reduction in carbopeptoid syntheses. NlmCategory="UNASSIGNED">We report the solid phase synthesis of -GG-X-GG- type α/β-carbopeptoids incorporating RibAFU(ip) (1a, tX) or XylAFU(ip) (2a, cX) sugar amino acids. Though coupling efficacy is moderate, both the lengthier sy...

Korobejnikov, I., 1960: Iran's economy in a blind alley. Iran's agriculture provides 80 per cent. of the total national income. More than 75 per cent, i.e. 14 million, of the population live and work in the country. Crop yields and animal production are very low. Work methods show a primitive stand...

Shoenfeld, Y., 2000: Eppur si muove (Galileo galilei 1564-1642): the idiotypic dysregulation of autoantibodies as part of the etiology of SLE. Lupus 9(7): 481-483

Kimura Hiroto; Watanabe Yoshio; Hamdi Bahaeddin, 1997: The end Vendian biotic crisis. The soft-bodied diacaran faunas almost disappeared from the fossil record in the end of the Vendian. A popular explanation for the disappearance is closure of a taphonomic window linked to the increased bioturbation during the the Cambrian Explosi...

Howells, T.H., 1965: Combination of propanidid with other anaesthetics (inhalants). Acta Anaesthesiologica Scandinavica. Supplementum 17: 39-39

Policello, George A., 2001: Terminally modified, amino, polyether siloxanes. The present invention teaches the composition of terminally modified, amino, polyether, siloxanes, known henceforth as amino siloxane alkokylates, and their use as adjuvants. The amino siloxane alkoxylates of the present invention enhance the effi...

Amich-Garcia, F.S.nchez-Rodriguez, J., 1985: Occurrence of Cosentinia vellea (Aiton) Tod. in the Province of Salamanca. Anales del Jardin Botanico de Madrid2(2): 530

Moorhouse, A.D.; Haider, S.; Gunaratnam, M.; Munnur, D.; Neidle, S.; Moses, J.E., 2008: Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Maintenance of telomeres - specialized complexes that protect the ends of chromosomes, is undertaken by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but is absent in most normal cells. T...

Sun, T.; Shao, L.; Zhao, Y., 2014: Prosthetic rehabilitation of an external auricle defect with silicone rubber using extrinsic staining. This clinical report describes a case of external auricle defect due to trauma. In the present report, a 23-year-old patient rehabilitated with an implant-retained 2-component room-temperature-vulcanizing silicone prosthesis showed success at the...