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Relationship between liver disturbance and mono amine oxidase ec 1.4.3.4 part 2 effect of amino acetonitrile on mono amine oxidase


, : Relationship between liver disturbance and mono amine oxidase ec 1.4.3.4 part 2 effect of amino acetonitrile on mono amine oxidase. Nichidai Igaku Zasshi 36(11-12): 1045-1054

When rat liver was centrifugally fractionated into microsome and the mitochondria fractions to observe the effects of AAN [aminoacetonitrile] on MAO [monoamine oxidase, EC 1.4.3.4] activity in each of them, the compound inhibited the activity in the former but increased the activity in the latter. The effects of AAN on the serum MAO in vitro were such that the compound increased the activity in acute liver disturbance, but depressed the activity in chronic disturbance. Electrophoresis gave an activity zone of the serum MAO that was not inhibited by AAN in acute disturbance, and an activity zone that was markedly inhibited by the compound in chronic disturbance. The serum MAO that increases in acute liver disease originates in the mitochondria, and the serum MAO that increases in chronic liver disease is derived from microsomes. AAN in vivo exerted such an effect on the liver with disturbance that morphologically the compound markedly inhibited not only hepatocytic disturbance but even fibrosis of the liver. The follow-up of the behavior of the serum MAO at given intervals disclosed that the serum MAO either in acute or chronic liver disturbance decreased on the administration of AAN. The former appeared to have secondarily resulted from the suppressed leakage of MAO from the mitochondria, while the latter was considered to be derived from the inhibition of the microsome MAO involved in fibrosis.

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