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Relationship between maternal anti blood group d levels fetal phenotype and hemolytic disease of the new born



Relationship between maternal anti blood group d levels fetal phenotype and hemolytic disease of the new born



Vox Sanguinis 35(5): 324-331



A lower level of maternal anti-D is required to produce the same symptoms of hemolytic disease of the newborn in R2r infants than in R1r infants. The higher site density of R2r cells may be associated with an increased association constant and thus they bind sufficiently more anti-D. The level at which amniocentesis should be considered was calculated to be 1.44 .mu.g anti-D/cm3 of maternal serum for R1r infants and 0.73 for R2 r infants.

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