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Relative biological activity of certain prostaglandins and their enantiomers



Relative biological activity of certain prostaglandins and their enantiomers



Prostaglandins 11(1): 77-84



A series of mirror image (ent) forms of prostaglandins (PG) F2 and E2 were compared for potency in a hamster antifertility test. In the PGF2 series ent-compounds surveyed had less potency than corresponding natural structures. For the PGE2 series 11.alpha.-(15S)-ent-PGE2 methyl ester was 10-fold more potent than PGE2. Altering the C-9 hydroxy configuration in the PGF2 series from the natural .alpha. to .beta. decreased potency dramatically for compounds tested.

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Accession: 006303614

Download citation: RISBibTeXText

PMID: 1257501

DOI: 10.1016/0090-6980(76)90175-1


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