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Relative distribution of coronary blood flow in rats with moderate and marked left ventricular hypertrophy



Relative distribution of coronary blood flow in rats with moderate and marked left ventricular hypertrophy



Canadian Journal of Physiology & Pharmacology 58(7): 830-835



A reduced capillary density associated with hypertrophy evoked by pressure overload may impose limitations on coronary flow. To determine the effect of moderate and marked left ventricular hypertrophy on regional myocardial blood flow at rest 53 anesthetized, open-chest rats were studied with radioactive 7-10 .mu.m microspheres. Spontaneously hypertensive (SHR) and aortic-constricted rats with left ventricular weight to body weight ratios 38 and 92% greater, respectively, than their normotensive controls provided a contrast between 2 distinct magnitudes of hypertrophy. Blood flow rates (left ventricular subendocardium to subepicardium and left to right septum) were used as indices of relative distribution of myocardial blood flow. Mean blood flow ratios were similar in hypertrophic and nonhypertrophic hearts despite the limitations of subnormal perfusion pressures inherent in the experimental conditions. Total left ventricular flow per unit mass was not altered by magnitude of hypertrophy. Circulatory adjustments and cardiac reserve in the hypertrophic myocardium are sufficient to maintain normal distribution of coronary flow under resting conditions, even when cardiac mass increases nearly 2-fold.

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