+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relative effects of asbestos and wollastonite on alveolar macrophages



Relative effects of asbestos and wollastonite on alveolar macrophages



Journal of Toxicology and Environmental Health 14(4): 497-510



Rabbit alveolar macrophages were exposed in culture to chrysotile asbestos, wollastonite, or latex, and the effects on various biochemical and physiological parameters related to cellular viability and fibrogenicity were determined. Exposure of alveolar macrophages to asbestos, wollastonite, or latex for 3 d has no effect on oxygen consumption or cellular volume. However, treatment of alveolar macrophages with as little as 25 micrograms asbestos/ml for 1 d increases lysosomal enzyme release and decreases membrane integrity, i.e., decreases trypan blue exclusion and increases leakage of cytosolic enzymes. In contrast, exposure of alveolar macrophages to wollastonite or latex at 250 micrograms/ml does not induce lysosomal enzyme release or alter membrane integrity even after 3 d of exposure in culture. These data suggest that chrysotile asbestos damages rabbit alveolar macrophages, while wollastonite, a potential substitute for asbestos, is far less cytotoxic.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 006303953

Download citation: RISBibTeXText

PMID: 6096570

DOI: 10.1080/15287398409530601


Related references

In vitro effects of crocidolite asbestos and wollastonite on pulmonary macrophages and serum complement. Scanning Electron Microscopy 1984(Pt 2): 919-926, 1984

Effects of asbestos and beryllium compounds on the alveolar macrophages. Medical Journal of Osaka University 27(1-2): 47-58, 1976

Effects of asbestos on the random migration of rabbit alveolar macrophages. Environmental Health Perspectives 60: 387-393, 1985

Surface alterations of asbestos and resulting effects on human pulmonary alveolar macrophages. Proceedings of the American Association for Cancer Research & American Society of Clinical Oncology 22: 72, 1981

Asbestos effects on superoxide production. An in vitro study of hamster alveolar macrophages. Environmental Research 39(2): 299-306, 1986

Cytotoxic effects of quartz and chrysotile asbestos: in vitro interspecies comparison with alveolar macrophages. Journal of Toxicology and Environmental Health 33(2): 131-140, 1991

Influence of surfactant components and exposure geometry on the effects of quartz and asbestos on alveolar macrophages. Environmental Health Perspectives 97: 225-231, 1992

Relative release of interleukin-1 beta and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis. Chest 104(1): 47-53, 1993

Contrasting effects of alveolar macrophages and neutrophils on asbestos induced pulmonary epithelial cell injury. American Review of Respiratory Disease 143(4 Part 2): A543, 1991

On the cytotoxicity of chrysotile asbestos fibers toward pulmonary alveolar macrophages. II. Effects of nicotinamide on the cell metabolism. Toxicology and Applied Pharmacology 98(1): 144-158, 1989

The cytotoxicity of chrysotile asbestos fibers to pulmonary alveolar macrophages. I. Effects of inhibitors of ADP-ribosyl transferase. Cell Biology and Toxicology 4(1): 13-30, 1988

In vitro and in vivo effects of asbestos on super oxide anion production by hamster alveolar macrophages and polymorphonuclear leukocytes. American Review of Respiratory Disease 125(4 Part 2): 57, 1982

The effect of asbestos on the enzymatic activity of alveolar macrophages. Journal of the Mississippi Academy of Sciences 26(Suppl.): 68, 1981

Asbestos induces apoptosis in human alveolar macrophages. American Journal of Physiology 271(5 Pt 1): L813-L819, 1996

In vitro phagocytosis of quartz and asbestos by rat alveolar macrophages. Elektronmikroskopievereniging van Suidelike Afrika Verrigtings (7): 129-130, 1977