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Release of intramural noradrenaline induced in rat uteri by depolarizing solutions of potassium



Release of intramural noradrenaline induced in rat uteri by depolarizing solutions of potassium



Archivos de Investigacion Medica 18(3): 207-212



The correlation between contractile activity and noradrenaline release induced by high potassium chloride solutions (40, 60, 70, 80, 90 and 123 mM) was studied in isolated preparations of rats uterus throughout the different phases of the estrous cycle, i.e. metaestrus (M), diestrus (D), proestrus (P) and estrus (E), and ovariectomized (OVX) rats uterus. The contractile response of rat uterus to potassium chloride rich media depended of the endocrine stage of the uterus. Thus, the uterus of OVX rats and in M, D, P and E phases exhibited a tonic contraction when immersed in a medium containing 40 mM KCl. Uteri from OVX, M and D phases showed an initial contraction followed by a transient relaxation when exposed to 60, 70, 80, 90 and 123 mM KCl. In the myometrium of rats in P and E phases, the transient relaxation stage was greatly diminished when exposed to 60, 70, 80, 90 and 123 mMKCl, and only presented tonic contractions. OVX uterine strips were relaxed significantly more by 123 mM KCl than uterine strips in P phase (p < 0.001). In uterine strips from OVX rats the addition of propranolol (20 UM) inhibited the transient relaxation observed with 123 mM KCl. In uterine strips from OVX rats previously charged with the radioactive transmitter, 40 mM KCl did not affect the efflux of noradrenaline labeled with tritium (3H-NA). In such conditions, it was observed that 123 mM KCl increased the efflux of 3H-NA. Propranolol (20 .+-.) did not affect the potassium chloride (123 mM) evoked 3H-NA release in uterine strips from OVX rats. The present study shows that the changes in uterine contractile response to chemical stimulation during the different phases of estrous cycle and OVX animals could be due to the action of sex steroids at presynaptic level by modulation of neurotransmitter release.

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