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Release of norepinephrine and dopamine from brain vesicular preparations effects of calcium antagonists

Release of norepinephrine and dopamine from brain vesicular preparations effects of calcium antagonists

Cellular & Molecular Neurobiology 2(3): 205-214

The Ca antagonists D-600 [methoxy verapamil] (1-10 .mu.M) and diltiazem (10-25 .mu.M) inhibit K+-evoked release of [3H]norepinephrine from guinea pig cerebral cortical vesicular preparations. The inhibition of release is partially reversed by increasing concentrations of calcium to 2 mM. Diltiazem at 100 .mu.M has no effect on K+-evoked release of [3H]norepinephrine at 0.15 mM Ca but does inhibit release at 2.0 mM Ca. The Ca antagonists nifedipine and dantrolene, agents purported to antagonize release of Ca from intracellular storage sites, have no effect on K+-evoked release of [3H]norepinephrine. The calcium antagonists, D-600 (1 .mu.M) and diltiazem (10 .mu.M), inhibit K+-evoked release of [3H]dopamine from guinea pig striatal vesicular preparations. Higher concentrations of drug, namely, 10 .mu.M for D-600 and 100 .mu.M for diltiazem, cause a potentiation rather than an inhibition of K+-evoked release. The potentiation is reduced in magnitude upon raising the extracellular Ca to 2.0 mM. Indeed, 10 .mu.M D-600 then inhibits K+-evoked release of [3H]dopamine. Putative Ca antagonists can have both inhibitory and facilitory effects on Ca-dependent K+-evoked release of catecholamines from central synaptic endings. Furthermore, certain peripheral Ca antagonists, such as nifedipine and dantrolene, may prove ineffective in central systems.

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Accession: 006306183

Download citation: RISBibTeXText

PMID: 7159902

DOI: 10.1007/bf00711148

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