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Release of platelet activating factor paf acether and 2 lyso paf acether from 3 cell types



Release of platelet activating factor paf acether and 2 lyso paf acether from 3 cell types



Agents & Actions 12(5-6): 711-713



The release and formation of PAF-acether [platelet activating factor] and of its deacetylated precursor (2-lyso PAF-acether) were determined on mouse macrophages (M.vphi.), human polymorphonuclear neutrophils (PMN) and rabbit platelets using specific secretagogue stimuli in the same experimental conditions. As opposed to M.vphi., PMN and platelets were good releasers of PAF-acether. However, the total amount of PAF-acether formed by M.vphi. and PMN was larger than that formed by platelets. The total amount of 2-lyso-PAF-acether varied also for the 3 cell types, with platelets being by far the best producer. Calculation of the amount of PAF-acether formed from 2-lyso-PAF-acether indicated that M.vphi. and PMN possess a higher acetylating ability than platelets.

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Accession: 006306280

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