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Release tests for indomethacin suppositories



Release tests for indomethacin suppositories



Yakuzaigaku 46(4): 276-282



The release tests for three commercial indomethacin suppositories of water-insoluble bases were carried out by two different methods, Muranishi method and Thomas modified method. For Muranishi method, the effects of the volume of release fluid in a cell, the pore size of membrane, and temperature on the drug release were studied. The drug release amount, in general, decreased with an increase in the fluid volume and with a decrease in the pore size but did not vary with temperature in the range of 37.0 to 39.0.degree. C. The effect of the fluid volume was presumed to be ascribed to an expanse (or dispersion) of suppository base, while one of the suppositories was emulsion-type and showed the release behavior somewhat different from that of other oleaginous base suppositories. On the other hand, the effect of the pore size was considered to be apparent because the pore volume of the membrane used (Millipore SSWP, AAWP, HAWP, and GSWP) decreases with a decrease in the pore size. For Thomas modified method, the effect of temperature on the drug release was studied. In contrast with the case of Muranishi method, the drug release amount increased with a rise in temperature. Further, the order of drug release of the three suppositories by Thomas modified method was different from that by Muranishi method.

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Accession: 006306628

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