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Reorganization in cortical subcortical integration in dogs during chronic haloperidol administration

Reorganization in cortical subcortical integration in dogs during chronic haloperidol administration

Zhurnal Vysshei Nervnoi Deyatel'nosti Imeni I P Pavlova 36(2): 375-384

The character of evoked potentials (EPs) dynamics to signal light stimulus during elaboration of avoidance reaction, allows to assert that during formation of adaptive activity functional balance is established of sensory and integrative-triggering brain parts or functional balance of "motor" and "sensory" integration regimes. Each of the studied subcortical structures is characterized by simultaneous but specific functioning both in the motor and sensory regimes; such conclusion is based on different dynamics of their EPs parameters: the changes of ones correspond to EPs dynamics in the visual cortical area, of the others-in the motor area. During chronic haloperidol administration, the reorganizations of intercentral relations are observed in 10-12 days after the beginning of drug administration. They may be considered as a succession of disturbances of functional balance between "sensory" and "motor" integration regimes: at first the sensory regime domination appears in which subcortical structures are chiefly and uniformly involved (ncd, pall and n. acc.); "motor" regime is weakened; then, as a result, a distortion of the "motor" regime of integration takes place. In this case a bradykinesia is developed.

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