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Reorganization in culture of thyroid follicular cells influence of collagen on the orientation of cell polarity



Reorganization in culture of thyroid follicular cells influence of collagen on the orientation of cell polarity



Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences Serie D Sciences Naturelles 291(1): 79-82



In contract with a collagen gel, porcine thyroid follicular cell form a basal pole. A monolayer, with the apical side facing the culture medium is formed when cells are seeded on a collagen layer. In contrast cells reorganize into follicle-like structures when they are embedded in the collagen gel. If vesicles which have their apical pole in contact with the culture medium are embedded in the gel, collagen-cell interaction induces the inversion of cell polarity giving follicular structures. In addition after being overlaid with a collagen layer, cells forming a monolayer reorganize into follicles. The apical pole is formed on the free surface of the monolayer or on the internal side of structures embedded in collagen which differentiate into follicles.

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Accession: 006312019

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