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Repair of platinum dna lesions in escherichia coli by a pathway which does not recognize dna damage caused by n methyl n' nitro n nitrosoguanidine or uv light

Repair of platinum dna lesions in escherichia coli by a pathway which does not recognize dna damage caused by n methyl n' nitro n nitrosoguanidine or uv light

Mutation Research 145(1-2): 35-42

The adaptive response is an inducible DNA-repair system which diminishes the mutagenic and toxic effects of alkylating agents. A mutant of E. coli constitutive for adaptive repair, BS21, was isolated. A spontaneous revertant of this strain, BS23, lacks the adaptive response. When compared to its wild-type parent, mutant BS21 showed an increased resistance to the killing and mutagenic effects of a compound which is not a classical alkylating agent, the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP). This resistance to cis-DDP was also found in strain BS23 which lacks the adaptive response. cis-DDP bound to the DNA of all 3 strains with the same efficiency. The effect of UV radiation was investigated and no significant difference was observed in the survival and mutagenesis of these strains. The resistance of BS21 and BS23 strains to cis-DDP may not be a consequence of the adaptive response or increased excision repair.

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