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Repair of potentially lethal radiation damage in mouse embryo


European Journal of Cancer 14(6): 649-651
Repair of potentially lethal radiation damage in mouse embryo
The ability of mouse embryo cells to repair potentially lethal damage was studied. Female mice of the 15th gestation day were irradiated with X-rays or neutrons, and embryos were removed at various times thereafter. Surviving fractions of embryo cells determined by colony formation method in vitro. Survivals increased rapidly if embryos were left in utero for more than 2 h after X-irradiation and reached a plateau at 4 h, indicating that embryo cells can repair potentially lethal damage. The magnitude of this kind of repair was found dose-dependent.

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Accession: 006312526

PMID: 658089

DOI: 10.1016/0014-2964(78)90299-2



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