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Repair synthesis of DNA after irradiation and its modification due to radioprotection in vivo



Repair synthesis of DNA after irradiation and its modification due to radioprotection in vivo



Folia Biologica 12(3): 196-200



Repair DNA synthesis was examined in [chinese hamster Cricetulus griseus] bone marrow cells exposed to LD 50/30 in vivo. Intensive repair synthesis took place during the irradiation, and the increase in 3HTdR [tritiated thymidine] uptake prevailed over the inhibitory effect of radiation and AET [aminoethylisothiouroniumbromide hydrobromide] upon DNA synthesis. After LD 50/30, the intensity of DNA repair was reduced. Application of AET resulted in an increase in repair DNA synthesis after irradiation, indicated by a significantly higher incorporation of 3HTdR.

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Accession: 006312678

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PMID: 992150



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