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Repair synthesis of DNA after irradiation and its modification due to radioprotection in vivo






Folia Biologica 12(3): 196-200

Repair synthesis of DNA after irradiation and its modification due to radioprotection in vivo

Repair DNA synthesis was examined in [chinese hamster Cricetulus griseus] bone marrow cells exposed to LD 50/30 in vivo. Intensive repair synthesis took place during the irradiation, and the increase in 3HTdR [tritiated thymidine] uptake prevailed over the inhibitory effect of radiation and AET [aminoethylisothiouroniumbromide hydrobromide] upon DNA synthesis. After LD 50/30, the intensity of DNA repair was reduced. Application of AET resulted in an increase in repair DNA synthesis after irradiation, indicated by a significantly higher incorporation of 3HTdR.

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Accession: 006312678

PMID: 992150



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