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Reparative processes in myo cardium under physical loading



Reparative processes in myo cardium under physical loading



Krovoobrashchenie 13(1): 3-7



Experimental myocardial infarction (EMI) was induced in rabbits by binding the anterior descending branch of the left coronary artery (LCA). The rabbits were divided into 3 groups: the 1st group consisted of animals kept under regular vivarium conditions (control); the 2nd group was subjected to 3 min, 3 times daily, running exercise on a treadmill at a rate of 1.5-1.75 km/h and the 3rd group was kept under hypokinesia. After occlusion of the LCA, a necrotic focus in the left ventricle anterior wall developed. The formation of a transition zone with preserved but dystrophically altered myocardial cells was also observed. The necrosis and dystrophic processes did not occur at the same time in the different groups of animals. The transmural infarction formed more frequently in rabbits subjected to treadmill exercise (TE). With necrosis, corresponding reparative processes of the myocardium began to develop with formation of a connective tissue cicatrix. A lag in connective tissue maturation was noted in animals subjected to TE. The concentration of RNA and SH-protein groups was raised more sharply in these animals; glycogen concentration decreased during all stages of the experiment.

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