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Repeated administration of tri iodo thyronine to rats enhances nigro striatal and meso limbic dopaminergic behavioral responses






Neuropharmacology 21(2): 159-162

Repeated administration of tri iodo thyronine to rats enhances nigro striatal and meso limbic dopaminergic behavioral responses

A once daily injection to rats of triiodothyronine (T3; 100 .mu.g/kg s.c.) for 10 days enhanced the locomotor responses of rats pretreated with tranylcypromine (5 mg/kg) to an injection into the nucleus accumbens of dopamine (5DA; .mu.g bilaterally), when tested 24 h after the last T3 administration. This treatment did not alter the control responses of tranylcypromine-pretreated rats to injection of saline (1 .mu.l bilaterally). Injection of T3 for 10 days enhanced the circling responses of unilateral nigrostriatal-lesioned rats to apomorphine (0.5 mg/kg) but not to methamphetamine (0.5 mg/kg). Repeated T3 administration evidently lowered basal striatal DA concentrations. The treatment also produced a trend towards reduced DA concentrations in the nucleus accumbens, although the difference did not reach statistical significance. Repeated T3 injection apparently caused an increased post-synaptic function of both the nigrostriatal and mesolimbic DA systems in rat brain.

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Accession: 006312864



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