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Repeated administration of tri iodo thyronine to rats enhances nigro striatal and meso limbic dopaminergic behavioral responses

Repeated administration of tri iodo thyronine to rats enhances nigro striatal and meso limbic dopaminergic behavioral responses

Neuropharmacology 21(2): 159-162

A once daily injection to rats of triiodothyronine (T3; 100 .mu.g/kg s.c.) for 10 days enhanced the locomotor responses of rats pretreated with tranylcypromine (5 mg/kg) to an injection into the nucleus accumbens of dopamine (5DA; .mu.g bilaterally), when tested 24 h after the last T3 administration. This treatment did not alter the control responses of tranylcypromine-pretreated rats to injection of saline (1 .mu.l bilaterally). Injection of T3 for 10 days enhanced the circling responses of unilateral nigrostriatal-lesioned rats to apomorphine (0.5 mg/kg) but not to methamphetamine (0.5 mg/kg). Repeated T3 administration evidently lowered basal striatal DA concentrations. The treatment also produced a trend towards reduced DA concentrations in the nucleus accumbens, although the difference did not reach statistical significance. Repeated T3 injection apparently caused an increased post-synaptic function of both the nigrostriatal and mesolimbic DA systems in rat brain.

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