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Repeated dexamethasone suppression test during depressive illness normalization of test results compared with clinical improvement

Journal of Affective Disorders 4(2): 93-102

Repeated dexamethasone suppression test during depressive illness normalization of test results compared with clinical improvement

Serial plasma cortisol concentrations were recorded under controlled conditions after an overnight dexamethasone suppression (DST) in 20 depressed patients with initially abnormal test results. The cortisol levels were related to clinical course., All 20 patients showed normalization of hypothalamic-pituitary-adrenal (HPA) hyperactivity, a mean of 3.4 .+-. 1.8 wk before clinical recovery was achieved. In 4 clinically remitted patients the endocrine disturbance as evidenced by abnormal DST results preceded a depressive relapse. DST results did not appear to be affected by psychotropic drugs including benzodiazepines.

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Accession: 006312906

PMID: 6213695

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