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Repeated high dose cyclo phosphamide 1 3 bis 2 chloroethyl 1 nitroso urea and vp 16 213 etoposide and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission



Repeated high dose cyclo phosphamide 1 3 bis 2 chloroethyl 1 nitroso urea and vp 16 213 etoposide and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission



European Journal of Cancer & Clinical Oncology 20(5): 593-600



In adult acute lymphocytic leukemia (ALL) cure is rare. The purpose of this study was to try to improve remission duration and survival by administration of 2 courses of high-dose chemotherapy, each followed by autologous bone marrow rescue, in 1st remission. Chemotherapy consisted of cyclophosphamide, BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] and VP-16-213 [etoposide]. Rescue bone marrow was fractionated over a discontinuous albumin gradient to minimize contamination with leukemic cells. Fourteen patients entered the study. Median total remission duration was 14 mo. Three patients relapsed after 1 course of treatment. Five patients relapsed after the 2nd course. Four patients died after the 2nd course; 2 patients remain alive and well in unmaintained remission, with a total remission duration of 42+ and 47+ mo. This regimen is apparently toxic but, with careful selection of patients, may lead to long-term unmaintained remissions.

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Accession: 006312968

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