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Repeated high dose cyclo phosphamide 1 3 bis 2 chloroethyl 1 nitroso urea and vp 16 213 etoposide and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission


European Journal of Cancer & Clinical Oncology 20(5): 593-600
Repeated high dose cyclo phosphamide 1 3 bis 2 chloroethyl 1 nitroso urea and vp 16 213 etoposide and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission
In adult acute lymphocytic leukemia (ALL) cure is rare. The purpose of this study was to try to improve remission duration and survival by administration of 2 courses of high-dose chemotherapy, each followed by autologous bone marrow rescue, in 1st remission. Chemotherapy consisted of cyclophosphamide, BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea] and VP-16-213 [etoposide]. Rescue bone marrow was fractionated over a discontinuous albumin gradient to minimize contamination with leukemic cells. Fourteen patients entered the study. Median total remission duration was 14 mo. Three patients relapsed after 1 course of treatment. Five patients relapsed after the 2nd course. Four patients died after the 2nd course; 2 patients remain alive and well in unmaintained remission, with a total remission duration of 42+ and 47+ mo. This regimen is apparently toxic but, with careful selection of patients, may lead to long-term unmaintained remissions.

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Accession: 006312968



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