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Repeated histamine inhalation tests in asthmatic patients



Repeated histamine inhalation tests in asthmatic patients



Journal of Allergy & Clinical Immunology 67(4): 285-289



Histamine inhalation tests were performed in 12 asthmatic patients using a 2-min tidal breathing inhalation technique. The tests were repeated on separate days with 30-, 60- and 120-min intervals between inhalation tests. On another day the inhalation tests were repeated 4 times with 40-min intervals between tests. The geometric mean provocative concentrations of histamine needed to cause a 20% fall in forced expiratory volume in 1 s (PC20) for the group on the latter study day were 1.67, 1.57 and 1.55 mg/ml (P > 0.25) indicating no change in sensitivity to inhaled histamine with repeated testing. Cumulative dose-response curves for drugs potentially affecting the airways or antagonizing histamine can apparently be constructed within 1 day using histamine inhalation tests. An individual PC20 result may be sensitively assessed by comparing it to a .+-. 2 SD range from the mean of a series of control or placebo PC20 values.

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Accession: 006312971

Download citation: RISBibTeXText

PMID: 7204784

DOI: 10.1016/0091-6749(81)90023-3


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