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Reproducibility in the measurement of retinal mean circulation time using fluorescein video angiography and an image analysis system



Reproducibility in the measurement of retinal mean circulation time using fluorescein video angiography and an image analysis system



Nippon Ganka Gakkai Zasshi 92(4): 687-693



Double determinations of retinal mean circulation time, using fluorescein video angiography and an image analysis system, were carried out in all measureable retinal vascular areas of 10 normal eyes at intervals of about 1 minute (Group 1), and on a different day (Group 2). No significant differences were found between the 1st and 2nd measurement of retinal mean circulation time. Linear regression function relating the 2nd to 1st measurement yielded the equation : y=0.93x .times. 0.22, r = 0.87, n = 47, (Group 1) y = 0.91x + 0.15, r = 0.81, n = 45. (Group 2). The averages of all the value derived from the formula: { x-y /(x + y)} .times. 100 was 6.4% (Group 1) and 11.2% (Group 2). From these results, this system was considered to have a satisfactory reproducibility as a clinical tool measuring retinal circulation. Flusing an injected dye bolus into the antecubital vein followed immediately by saline injection and use of an inner fixation target were effective in improving the accuracy and reproducibility of the measurement of retinal mean circulation time using the system.

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Accession: 006315122

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PMID: 3407570


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