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Reproducibility of maximum expiratory flow in severe chronic obstructive pulmonary disease



Reproducibility of maximum expiratory flow in severe chronic obstructive pulmonary disease



Bulletin Europeen de Physiopathologie Respiratoire 15(6): 1129-1136



Reproducibility of maximum expiratory flow at 50% of vital capacity (.ovrhdot.Vmax50) in 24 patients with chronic bronchitis and/or emphysema, to establish whether the variability in these patients was greater than in normal individuals. The possibility that this variability could be reduced by using a smaller flowmeter was investigated. An average of 10 maximum expiratory flow-volume curves per patient was obtained using a body plethysmograph. Mean .ovrhdot.Vmax50 using a no. 4 Fleisch pneumotachygraph was 0.91 l/s (SD = 0.35) and using a no. 2 was 0.89 l/s (SD = 0.41); P = NS [not significant]. Mean coefficient of within patient variation for no. 4 pneumotachygraph was 13.6% (range 4.6-32.1) and for no. 2 was 15.1% (range 5.5-32.7); P = NS. The coefficient of variation was higher than that reported in normals and in patients with less severe airway obstruction. This high variability should be considered when assessing the effects of treatment and of altered gas density in patients with moderate to severe airway obstruction.

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Accession: 006315205

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PMID: 554690


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