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Reproducibility of multistage graded exercise testing in patients with chronic stable angina



Reproducibility of multistage graded exercise testing in patients with chronic stable angina



International Journal of Cardiology 6(2): 137-146



Exercise testing is widely used for the diagnosis of ischemic heart disease and for the evaluation of antianginal drugs. To assess reproducibility, analysis was carried out on 128 paired graded exercise tests from 103 patients performed at the same time of day and under identical conditions. Six different parameters were evaluated and compared between the basal test (no treatment) and the placebo test. During the basal period the mean (.+-. SEM [standard error of the mean]) exercise time to the development of angina was 6.0 (.+-. 0.2) min and the 1 mm ST depression time was 4.1 (.+-. 0.2) min. After 2 wk of placebo the exercise time was 6.1 (.+-. 0.2) min (P = NS [not significant]) and the 1 mm ST depression time was 4.2 (.+-. 0.2) min (P = NS). There was no significant difference between the resting or maximum heart rate on either test and the maximum ST segment depression (leads CM5 and CC5) was unaltered. In a 2nd group of 17 patients where the basal tests were performed in the afternoon and the placebo tests in the morning, heart rate and ST segment were found to be reproducible but there was a significant difference in exercise time: 5.7 (.+-. 0.7) min for the basal test and 8.3 (.+-. 0.5) min for the placebo test (P < 0.001); and of the 1 mm ST depression time: 2.7 (.+-. 0.4) min for the basal test, and 5.4 (.+-. 0.5) min for the placebo test (P < 0.001). Exercise tests done under standardized conditions in the morning are highly reproducible in patients with chronic stable angina provide a valuable test for the evaluation of antianginal drugs.

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Accession: 006315216

Download citation: RISBibTeXText

PMID: 6469401

DOI: 10.1016/0167-5273(84)90346-2


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