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Reproducibility of syphilis serology results

Reproducibility of syphilis serology results

American Journal of Clinical Pathology 74(4 Suppl.): 586-588

To evaluate the stability and reproducibility of syphilis serology qualitative results, the results reported on replicate specimens in the College of American Pathologists Quality Evaluation Program during 1978 were examined. There is evidence of good stability of syphilis serology specimens and reproducibility of qualitative results separated in time by as much as 9 mo. for specimens that are nonreactive or highly reactive. There is evidence of lack of such stability and reproducibility of weakly reactive specimens. There is no striking difference in these results for the RPR [rapid plasma reagin] card or VDRL [Venereal Disease Research Laboratories] test. The FTA-ABS [fluorescent treponemal antibody absorption] test is more stable over time. There is some indication that the lack of stability and reproducibility of weakly reactive specimens is primarily a function of the stability of the specimen, with laboratory performance playing a secondary role.

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Accession: 006315270

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PMID: 7435452

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