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Reproducible sub cellular alterations in hepatocytes resulting from ultrasound



Reproducible sub cellular alterations in hepatocytes resulting from ultrasound



Ultrasound in Medicine & Biology 6(3): 239-250



Reproducible ultrastructural alterations in subcellular organelles were produced with ultrasonic exposure in mice. Mitochondria were the most sensitive organelle, exhibiting swelling, electron-dense condensations in the matrix, loss of cristae and the formation of lamellar membranes, with eventual disruption of the outer membrane. The endoplasmic reticulum was less sensitive, but showed a graded response to increasing exposure including dilation of the cisternae, loss of ribosomes from the surface and vesiculation. Lysomes retained their structural integrity better than other cytoplasmic organelles. If the level of exposure was not lethal to the cell most of the changes were repaired within 96 h; mitochondrial changes persisted for longer periods and may be irreversible. The mechanism of mitochondrial injury and recovery required further study.

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Accession: 006315346

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PMID: 7414747


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