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Reproduction function in hyperadrenocorticism and hypoadrenocorticism



Reproduction function in hyperadrenocorticism and hypoadrenocorticism



Revue Roumaine de Medecine Endocrinologie 21(2): 123-130



Patients (66) with hypo- or hyperfunctional syndromes of adrenocorticism; were studied. Patients 34 females with Cushing's syndrome, 10 males with Cushing's syndrome, 10 males with Addison's disease, and 6 females with androgenic hypercoricism. The morphofunctional disorders of reproduction were followed up clinically and by complex hormone assays, before and after treatment. The incidence of these disorders is very high, and the results of clinical observations and of laboratory data demonstrate that both the excess of adrenocortical hormones and the decrease in their circulating level have a negative influence on the reproduction function or represent a risk factor in cases of pregnancy. By the curative treatment of the adrenal cortex, prevention of abortion and/or sterility is achieved.

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