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Reproduction of passive avoidance in rats by administering pharmacological agents



Reproduction of passive avoidance in rats by administering pharmacological agents



Zhurnal Vysshei Nervnoi Deyatel'nosti Imeni I P Pavlova 31(1): 158-163



Rats learned passive avoidance reaction in 1 trial with subsequent administration of electroconvulsive shock (2 h after learning). The influence of different factors on the retrieval of the lost reaction was tested after 3 days. The greatest restoring capacity was exhibited by a non-specific reminding agent, the bell, GABA (200 mg/kg) and etimizol (1.5 mg/kg). In animals with a preserved reaction, a number of pharmacological agents impaired retrieval of the habit (caffeine 5 mg/kg, carbocholine 0.01 mg/kg and metamizil 0.5 mg/kg). Optimal conditions for the restoration of the lost reaction were formed by etimizol and GABA. Cholinergic mechanisms play a certain role in the functioning of the retrieval apparatus.

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Accession: 006315929

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PMID: 6113722


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