Resistance to anaplasmosis after elimination of latent Anaplasma marginale infections

Richey, E.J.; Brock, W.E.; Kliewer, I.O.; Jones, E.W.

American Journal of Veterinary Research 38(2): 169-170


ISSN/ISBN: 0002-9645
PMID: 557302
Accession: 006321146

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Ten 30 mo. old cattle (group 2) were inoculated with A. marginale 6 mo. after the latent A. marginale infection was eliminated by oral chlortetracycline therapy. Four cattle (group 1) with no record of infection and 4 cattle (group 3) of equivalent age previously vaccinated with a killed antigen were similarly inoculated. Moderate to severe clinical signs of acute anaplasmosis occurred in the group 1 (previously uninfected) cattle; only 1 of the chlortetracycline-treated cattle (group 2) and none of the vaccinated cattle (group 3) had clinical evidence of disease. Even with half of their erythrocytes destroyed, animals are apparently sufficiently immunocompetent to clear infections.