Response of high density lipoprotein cholesterol apoprotein a i and lecithin cholesterol acyltransferase to exercise withdrawal

Thompson, C.E.; Thomas, T.R.; Araujo, J.; Albers, J.J.; Decedue, C.J.

Atherosclerosis 54(1): 65-74


ISSN/ISBN: 0021-9150
Accession: 006325700

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The effect of short-term exercise withdrawal on plasma lipoproteins, apoprotein A-I (Apo A-I) and lecithin:cholesterol acyltransferase (LCAT) was studied in moderately trained lifestyle exercisers. Eight endurance-trained men, age 18-45 yr (.hivin.X = 29 yr), withdrew from aerobic activity for 6 wk, while an age and fitness-matched control group (n = 9) maintained normal exercise habits. A baseline period that included 2 blood samplings preceded the detraining intervention. Plasma total cholesterol (TCHOL), HDL cholesterol (HDL-C) and triglyceride (TG) levels were determined weekly. Other blood variables (HDL2-C, HDL3-C, Apo A-I and LCAT), % fat and aerobic capacity (.ovrhdot.VO2 max) were measured pre-, mid- and post-experiment. A 2-way repeated measures analysis of variance (ANOVA) indicated that the 6-wk exercise withdrawal period failed to elicit significant mean changes in any blood variable, % fat of .ovrhdot.VO2 max. A short-term layoff from aerobic activity by moderately trained, chronic exercisers generally does not adversely affect the blood lipoprotein profile, aerobic capacity or risk of atherosclerosis.