Restriction specificity of virus-specific cytotoxic T cells from thymectomised irradiated bone marrow chimeras reconstituted with thymus grafts

Zinkernagel, R.M.

Thymus 2(6): 321-327

1981


ISSN/ISBN: 0165-6090
PMID: 6168044
Accession: 006331365

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Abstract
Adult-thymectomized lethally irradiated mice A that were reconstituted with T-cell-depleted bone marrow cells of (A .times. B)F1 origin plus fetal thymus grafts of (B .times. C)F1 origin generated virus-specific T cells restricted to B alone; adult-thymectomized and lethally irradiated (A .times. B)F1 mice that were reconstituted with T-cell-depleted bone marrow cells of (A .times. B)F1 origin plus fetal thymus grafts of A and of B origin generated virus-specific T cells restricted to A or to B. Obvious suppressive influences of host or stem-cell origin that might have explained results obtained with various irradiated bone marrow or thymus chimeras were not seen. The thymus' influence on maturing T cells probably is one of the limiting steps in the selection of T cells' restriction specificities.