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Results of the treatment of hodgkin's disease in stages iii and iv with use of the doxorubicin bleomycin vinblastine dacarbazine and bleomycin doxorubicin cyclophosphamide vincristine prednisone programs

Results of the treatment of hodgkin's disease in stages iii and iv with use of the doxorubicin bleomycin vinblastine dacarbazine and bleomycin doxorubicin cyclophosphamide vincristine prednisone programs

Acta Haematologica Polonica 17(3-4): 81-90

The reported investigations were carried out in 60 patients in advanced stages of Hodgkin's disease resistant to conventional treatment (MOPP/MVPP, COPP, COPP/CVPP, ionizing radiation). The follow-up was 5 years. The patients received chemotherapy by schedules BACOP and ABVD and the selection to either group was done randomly. The proportion of complete remissions was 23.7% and their mean duration was 23.3 months. The percent of remissions obtained in groups treated according to schedules ABVD and BACOP was 35.7% and 50% respectively. No difference was observed in the duration of remission. The mean survival time in the group with complete remission was 40.1 months and in those without remission.sbd.24.2 months. Among patients with complete remission one died of another neoplasm. In the group without remission 25 patients died, 24 of them died due to progression of Hodgkin's disease. Early complications after the treatment were observed in 73% of patients. The most important among them were transient signs of marrow suppression (leucopenia in 28 cases).

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