Results of treatment of adjuvant induced polyarthritis in rats with levamisole

Nowak, H.F.; Cylwik, B.; Duda, D.; Glowinska, L.

Reumatologia 23(3): 191-196

1985


ISSN/ISBN: 0034-6233
Accession: 006333502

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Abstract
The effect of levamisole injected subcutaneously twice weekly in doses of 2.5 mg/kg on the course of adjuvant-induced polyarthritis was studied in Wistar rats. The experiment lasted 8 weeks. The regression of swelling and reddening of paws between the second and the sixth weeks of the experiment was more pronounced in rats treated with levamisole (group II) as compared with untreated rats (group I). The mean body mass of rats in group II was lower than in group I. White blood cell counts failed to demonstrate any depressing effect of the drug given in these doses on bone marrow granulopoiesis.