Rift valley fever virus and hemorrhagic fever in the central african republic

Gonzalez, J.P.; Bouquety, J.C.; Lesbordes, J.L.; Madelon, M.C.; Mathiot, C.C.; Meunier, D.M.Y.; Georges, A.J.

Annales de l'Institut Pasteur Virology 138(3): 385-390


ISSN/ISBN: 0769-2617
Accession: 006344073

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Rift Valley fever virus (RVFV), primarily identified in the Central African Republic as Zinga virus, has been isolated from arthropods and humans, among whom it may be responsible for either mild disease or haemorrhagic fever. We were recently able to isolate RVFV in four patients presenting haemorrhagic symptoms, with subsequent evolution to death in three cases and one recovery. Over the past eight years, human and animal sera from CAR have been screened for RVFV antiobodies using indirect immunofluorescence. Fluorescent antibodies ranged from 0% to 4.5% depending on the area surveyed. The dramatic increase in livestock over the past five years represents a potential domestic reservoir for the virus. This new epidemiological status is analysed and then discussed.