EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Risk factors for fibrocystic breast disease and its histopathologic components






Journal of the National Cancer Institute 75(1): 43-50

Risk factors for fibrocystic breast disease and its histopathologic components

The relationship between various sociodemographic, reproductive, and other factors to the occurrence of fibrocystic breast disease was evaluated in a case-control study undertaken at five Connecticut hospitals from 1979 to 1981. The study groups comprised 590 women with biopsy-proven fibrocystic breast disease and 1,018 women with other surgical conditions. Among the premenopausal women, multivariate analysis suggested that high socioeconomic status, Jewish religion, low parity, a history of benign breast disease, a history of breast cancer in the mother or a sister, and low Quetelet index were associated with increased odds ratios (OR) for fibrocystic breast disease. Similar analysis for the postmenopausal women revealed increased OR for women with high socioeconomic status, a late age at menopause, and a history of benign breast disease. Current smokers as well as those who had had a tubal sterilization had significantly reduced odds of fibrocystic disease. There was no convincing evidence of linear trends according to degree of epithelial atypia for any of the variables considered. Although some variation in the OR emerged in the analysis according to selected histologic components, the results provided little evidence that women with biopsy specimens exhibiting gross cysts, sclerosing adenosis, papillary hyperplasia, or papillomatosis showed epidemiologic similarities with breast cancer patients.


Accession: 006345196

PMID: 3859695



Related references

Berkowitz G.S.; Kelsey J.L.; Livolsi V.A.; Merino M.J.; Holford T.R.; Hildreth N.G.; Ort S.; O'connor T.Z.; White C., 1984: Exogenous hormone use and fibrocystic breast disease by histopathologic component. In a hospital-based case-control study of 590 women with biopsy-proven fibrocystic breast disease and 1018 control women with other surgical conditions, no linear relationship was evident between the use of oral contraceptives or of estrogen repla...

Wu, C.; Ray, R.M.; Lin, M.Gang.; Gao, D.Li.; Horner, N.K.; Nelson, Z.C.; Lampe, J.W.; Hu, Y.Wei.; Shannon, J.; Stalsberg, H.; Li, W.; Fitzgibbons, D.; Porter, P.; Patterson, R.E.; Satia, J.A.; Thomas, D.B., 2004: A case-control study of risk factors for fibrocystic breast conditions: Shanghai Nutrition and Breast Disease Study, China, 1995-2000. This study was conducted to identify reproductive and dietary factors associated with benign proliferative mammary epithelial cell changes. Subjects were women enrolled in a randomized trial of breast self-examination in Shanghai, China. Women who...

Page, D.L.; Dupont, W.D., 1988: Histopathologic risk factors for breast cancer in women with benign breast disease. Mammary epithelial hyperplasia indicates an increased likelihood of carcinoma development as it does in other organs. Prospective studies have demonstrated that in the premammography era about 70% of women undergoing surgical biopsy had no increas...

Spigolon, G., 1951: Critical, morphological, and histopathogenic considerations on fibrocystic breast disease; fibrocystic disease and carcinoma of the breast. Archivio Italiano di Anatomia E Istologia Patologica 24(6): 473-514

Li, W.; Ray, R.M.; Lampe, J.W.; Lin, M-Gang.; Gao, D.Li.; Wu, C.; Nelson, Z.C.; Fitzgibbons, E.Dawn.; Horner, N.; Hu, Y.Wei.; Shannon, J.; Satia, J.A.; Patterson, R.E.; Stalsberg, H.; Thomas, D.B., 2005: Dietary and other risk factors in women having fibrocystic breast conditions with and without concurrent breast cancer: a nested case-control study in Shanghai, China. Risk of breast cancer is increased in women with proliferative benign breast conditions. Most of these conditions, however, do not progress to breast cancer. The purpose of our study was to identify factors possibly associated with this progressio...

Masood, S., 2005: Cytomorphology of fibrocystic change, high-risk proliferative breast disease, and premalignant breast lesions. In a prospective study using mammographically guided fine needle aspirates in 100 nonpalpable breast lesions, the author's group assessed the reliability of a cytological grading system to define the cytological features of proliferative and...

Gratterola, R., 1978: Anovulation and increased androgenic activity as breast cancer risk in women with fibrocystic disease of the breast. Urine of 26 otherwise healthy women with fibrocystic breast disease (FCD) was assayed by gas chromatography for testosterone (Tes) and androstanediol (Ans), the major metabolite of dihydrotestosterone. The 26 patients under study had been subjecte...

Hockenberger, S.J., 1993: Fibrocystic breast disease: every woman is at risk. Fibrocystic breast disease refers to a constellation of breast changes observed in premenopausal women, and 90% of all women experience evidence of pathophysiologic changes in the breast during their lifetime. Although most breast changes are harm...

Petrakis N.L., 1989: Estrogens and other biochemical and cytological components in nipple aspirates of breast fluid relationship to risk factors for breast disease. Proceedings of the Royal Society of Edinburgh Section B (Biological Sciences) 95: 169-182

Guinebretière, J.M.; Lê Monique, G.; Gavoille, A.; Bahi, J.; Contesso, G., 1994: Angiogenesis and risk of breast cancer in women with fibrocystic disease. Journal of the National Cancer Institute 86(8): 635-636