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Risk of cervical cancer associated with mild dyskaryosis


, : Risk of cervical cancer associated with mild dyskaryosis. Bmj 297(6640): 18-21

In a survey of 1781 patients who had mild dyskaryosis in a cervical smear taken between 1965 and 1984 invasive cancer occurred in 10 women. In four cancer was diagnosed soon after presentation, and in three it developed some years after default from follow up. Invasion occurred in one patient during cytological surveillance and in a further two after referral for colposcopic supervision. A poor correlation was found between a single cervical smear showing mild dyskaryosis and biopsy results. This was, however, improved by a series of smears. During initial surveillance cervical smear results reverted to normal in 46% of our patients within two years. During longer term follow up none of these patients developed invasive cancer, and life table analysis showed that three quarters had not relapsed after 14 years. We also found no evidence to suggest that preinvasive disease is more rapidly progressive in younger women. Our results indicate that cytological surveillance is acceptably safe provided that biopsy is advised if dyskaryosis persists.

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Accession: 006345528

PMID: 3408902

DOI: 10.2307/29700024

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Related references

Anonymous, 1988: Cervical cancer associated with mild dyskaryosis. Bmj 297(6648): 617-618

Berkhof, J.; de Bruijne, M.C.; Zielinski, G.D.; Bulkmans, N.W.J.; Rozendaal, L.; Snijders, P.J.F.; Verheijen, Ré.H.M.; Meijer, C.J.L.M., 2005: Evaluation of cervical screening strategies with adjunct high-risk human papillomavirus testing for women with borderline or mild dyskaryosis. The management of women with a smear read as borderline/mild dyskaryosis (BMD) found by cervical cancer screening is still under discussion as only few of these cases are associated with high-grade lesions. To determine the optimal screening strat...

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