EurekaMag.com logo
+ Translate

Risks to the offspring of patients with some common congenital heart defects


, : Risks to the offspring of patients with some common congenital heart defects. Journal of Medical Genetics 18(1): 8-16

The families of 424 adult index patients with ventricular septal defect, right ventricular outflow tract obstruction, or combinations of these two abnormalities, were visited and interviewed, and whenever possible the children of index patients were examined clinically. Congenital heart defects were present in 9 of 308 children, 8 of 899 sibs, 4 of 840 parents, and 4 of 731 nephews and nieces of the index patients. The last three figures are likely to be underestimates owing to the design of the study. Comparison of pairs of affected relatives suggests that the group of lesions studied may have genetic determinants in common.

(PDF same-day service: $19.90)

Accession: 006345827

PMID: 7253006

DOI: 10.1136/jmg.18.1.8

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Burn, J., 1983: Congenital heart defects--the risks to offspring. Archives of Disease in Childhood 58(12): 947-948

Burn J., 1983: Congenital heart defects the risks of offspring. Archives of Disease in Childhood 58(12): 947-948

Driscoll D.J.; Michels V.; Gersony W.M.; Hayes C.J.; Keane J.F.; Kidd B.S.L.; O'fallon W.M.; Pieroni D.R.; Wolfe R.R.; Weidman W.H., 1989: Occurrence of congenital heart defects in offspring of patients with ventricular septal defect aortic stenosis or pulmonary stenosis results of the second natural history study of congenital heart defects. Journal of the American College of Cardiology 13(2 SUPPL A): 136A

Sun, J.; Chen, X.; Chen, H.; Ma, Z.; Zhou, J., 2016: Maternal Alcohol Consumption before and during Pregnancy and the Risks of Congenital Heart Defects in Offspring: A Systematic Review and Meta-analysis. Epidemiologic studies have reported conflicting results regarding maternal alcohol consumption before and during pregnancy, and the risk of congenital heart defects (CHDs). However, a systematic review and meta-analysis of the association between...

Wen, Z.; Yu, D.; Zhang, W.; Fan, C.; Hu, L.; Feng, Y.; Yang, L.; Wu, Z.; Chen, R.; Yin, K-Jie.; Mo, X., 2016: Association between alcohol consumption during pregnancy and risks of congenital heart defects in offspring: meta-analysis of epidemiological observational studies. To explore the association between maternal alcohol consumption and/or binge drinking and congenital heart defects (CHDs), we conducted a meta-analysis for more sufficient evidence on this issue. We searched Medline, EMBASE, and the Cochrane Libra...

Romano Zelekha, O.; Hirsh, R.; Blieden, L.; Green, M.S.; Shohat, T., 2001: The risk for congenital heart defects in offspring of individuals with congenital heart defects. Background: Congenital heart defects (CHDs) occur in approximately 1% of all live births. Although most CHDs are of unknown etiology, a family history of CHDs is a known risk factor, and offspring of individuals with CHDs are at a higher risk of h...

Stingone, J.A.; Luben, T.J.; Daniels, J.L.; Fuentes, M.; Richardson, D.B.; Aylsworth, A.S.; Herring, A.H.; Anderka, M.; Botto, L.; Correa, A.; Gilboa, S.M.; Langlois, P.H.; Mosley, B.; Shaw, G.M.; Siffel, C.; Olshan, A.F., 2015: Maternal exposure to criteria air pollutants and congenital heart defects in offspring: results from the national birth defects prevention study. Epidemiologic literature suggests that exposure to air pollutants is associated with fetal development. We investigated maternal exposures to air pollutants during weeks 2-8 of pregnancy and their associations with congenital heart defects. Mother...

Nora J.J.; Dodd P.F.; Leachman R.D.; Sommerville R.J.; Mcnamara D.G., 1969: Prevalence of anom congenital heart defects among offspring of parents with anom congenital heart disease abstract multi factorial inheritance. American Journal of Cardiology 23(1): 131

Lupo, P.J.; Symanski, E.; Langlois, P.H.; Lawson, C.C.; Malik, S.; Gilboa, S.M.; Lee, L.J.; Agopian, A.J.; Desrosiers, T.A.; Waters, M.A.; Romitti, P.A.; Correa, A.; Shaw, G.M.; Mitchell, L.E., 2013: Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study. There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conduc...

Siu, S., 2005: The risk of congenital heart disease recurrence in the offspring of adults with major heart defects. Evidence-Based Cardiovascular Medicine 2(3): 70-70