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Role of inactivation of lung tissue sulfhydryl compounds in the pathogenesis of pulmonary edema



Role of inactivation of lung tissue sulfhydryl compounds in the pathogenesis of pulmonary edema



Fiziolohichnyi Zhurnal (Kiev) 22(3): 400-405



The ability of 8 inhibitors of sulfhydryl groups with different chemical structure and various mechanisms of the thioloprive effect to induce pulmonary edema was shown in experiments with 199 albino rats. Development of edema was accompanied by a decrease in the SH[sulfhydryl]group concentration determined by amperometric titration and by a release in intensity of the lung tissue histochemical response to sulfhydryl compounds. The weak ability of monoiodoacetic acid to cause edema was intensified considerably by a subedemogenic dose of adrenalin. Inactivation of the lung membrane SH-groups is considered an essential pathogenic mechanism which disturbs permeability.

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Accession: 006351008

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