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Role of inducible enzymes on excretion of mutagenic metabolites in urines of rats treated with metronidazole



Role of inducible enzymes on excretion of mutagenic metabolites in urines of rats treated with metronidazole



Bollettino Societa Italiana Biologia Sperimentale 61(11-12): 1595-1602



Urines from rats treated via i.p. with metronidazole, a drug widely used for the treatment of protozoan infection, have been shown to be highly mutagenic on Salmonella typhimurium TA 100 tester strain. Moreover, involvement of cytochrome P-450 into oxidative metabolism of metronidazole has been shown. In particular, cytochrome P-448 and other hepatic mixed function oxidase enzymes inducible by methylcholantrene pretreatment were the most efficient in transforming metronidazole into its high mutagenic urinary metabolite 1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole.

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Accession: 006351027

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